Research Research

最小化 最大化

1.  Bioconjugation of viral nanoparticles for biomedical application

Viral nanoparticles (VNPs) have emerged as promising building blocks for chemical reactions and materials syntheses in recent years. These bio-inspired systems form monodispersed units with nano-scale size, and have sophisticated yet highly ordered structural features. Therefore, viruses offer a unique scaffold where functional motifs can be programmed on their coat proteins precisely at sub-nanometer scale via bioconjugation recognition, which is a big advantage over synthetic nanoparticles. Based on these bioconjugation strategies, VNPs have been decorated with a wide spectrum of functionalities for the tissue engineering, drug delivery, bioimaging, biosensing and vaccine development.

 

Nano Res. 2010, 2, 349-364; ChemBioChem 2008, 9, 519-523; Biomacromolecules 2012, 13, 422-431; Bioconjugate Chem. 2010, 21, 1369-1377; J. Mater. Chem. 2010, 20, 5715-5719; RSC Adv. 2014, 4, 23017-23021.

2. Development of hierarchically organized structures for tissue engineering

2D patterns of viral nanoparticles (VNPs) have been fabricated for the direction of cell behavior and the development of tissue engineering materials. Either using the confined evaporation method, flow assembly in a glass capillary tube, or inkjet printing technology, VNPs could be aligned in large area stripe patterns which was perpendicular or hierarchical to the long axis of capillary tube, providing the biophysical and biochemical signal to support cell growth and guide the cell orientation. P3HT, CNTs, and polyaniline/TMV fibers are now applied for the fabrication of 2D patterned structures to meet the needs of electrical property for tissue engineering materials. Furthermore, to mimic the spatially patterned extracellular environment in vivo, we are also pursuing the development of 3D orientated and spatially patterned hydrogel for new tissue engineering materials.

 

Chem. Commun2008, 5185-5187; Angew. Chem. Int. Ed. 2010, 49, 868-872; ACS Nano 2013, 7, 8385-8396; Biomacromolecules 2012, 13, 3949-3958; Phys. Chem. Chem. Phys. 2012, 14, 16286-16293.

3. Fabrication of novel soft materials driven by supramolecular interactions 

Due to the covalent chemical modificationcon are irreversible, and normally require long reaction times and lengthy purification steps to introduce functional groups in the synthesis. Consequently, supramolecular interactions are becoming more attractive because it is easy to realize the predictable change through attaching different stimuli-responsive groups on the basis of noncovalent synthesis, including hydrogen bonds, pi-stacking, charge-transfer (CT) interactions, electrostatic interactions, and host-guest complexation. We are trying to use supramolecular interactions in fabricating various multifunctional soft materials to load imaging agents, targeting ligands, and chemotherapeutic drugs for biomedical applications. 
 

Nanoscale, 2015, 7, 13568-13575; Chem. Commun. 2014, 50, 14125-14128; Polym. Chem. 2014, 5, 6754-6760; Chem. Eur. J., 2014, 20, 7603-7607; Chem. Asian. J., 2014, 50, 11950-11953.