1. Bioconjugation of viral nanoparticles for biomedical application
Viral nanoparticles (VNPs) have emerged as promising building blocks for chemical reactions and materials syntheses in recent years. These bio-inspired systems form monodispersed units with nano-scale size, and have sophisticated yet highly ordered structural features. Therefore, viruses offer a unique scaffold where functional motifs can be programmed on their coat proteins precisely at sub-nanometer scale via bioconjugation recognition, which is a big advantage over synthetic nanoparticles. Based on these bioconjugation strategies, VNPs have been decorated with a wide spectrum of functionalities for the tissue engineering, drug delivery, bioimaging, biosensing and vaccine development.
Nano Res. 2010, 2, 349-364; ChemBioChem 2008, 9, 519-523; Biomacromolecules 2012, 13, 422-431; Bioconjugate Chem. 2010, 21, 1369-1377; J. Mater. Chem. 2010, 20, 5715-5719; RSC Adv. 2014, 4, 23017-23021.
2. Development of hierarchically organized structures for tissue engineering
2D patterns of viral nanoparticles (VNPs) have been fabricated for the direction of cell behavior and the development of tissue engineering materials. Either using the confined evaporation method, flow assembly in a glass capillary tube, or inkjet printing technology, VNPs could be aligned in large area stripe patterns which was perpendicular or hierarchical to the long axis of capillary tube, providing the biophysical and biochemical signal to support cell growth and guide the cell orientation. P3HT, CNTs, and polyaniline/TMV fibers are now applied for the fabrication of 2D patterned structures to meet the needs of electrical property for tissue engineering materials. Furthermore, to mimic the spatially patterned extracellular environment in vivo, we are also pursuing the development of 3D orientated and spatially patterned hydrogel for new tissue engineering materials.
Chem. Commun. 2008, 5185-5187; Angew. Chem. Int. Ed. 2010, 49, 868-872; ACS Nano 2013, 7, 8385-8396; Biomacromolecules 2012, 13, 3949-3958; Phys. Chem. Chem. Phys. 2012, 14, 16286-16293.
3. Fabrication of novel soft materials driven by supramolecular interactions
Nanoscale, 2015, 7, 13568-13575; Chem. Commun. 2014, 50, 14125-14128; Polym. Chem. 2014, 5, 6754-6760; Chem. Eur. J., 2014, 20, 7603-7607; Chem. Asian. J., 2014, 50, 11950-11953.